Piesie Esther released her debut album “Apae Ama Me” in 2002. She followed this with “Me Nte Ase” in 2008, which earned nominations at Ghana’s national music awards the following year. Her third album, “Ziba Beko“, appeared in 2011, and she released “Agye Won Nsem” in 2016. In 2017 she released a worship-album titled “Osoreɛ Mu Tumi“. Among her notable singles is “Wayɛ Me Yie“, which achieved significant airplay in Ghana. 

In 2023, Piesie Esther won the Gospel Artiste of the Year and Best Gospel Song awards at the 24th Vodafone Ghana Music Awards (VGMA).

In 2024, she was named Gospel Act of the Year at the 3Music Awards.